R&D Allocationv1 · 10.13
Does an antibody that binds well make a good development candidate? ↗
How reliably can research AI lead to antibody candidates that meet the requirements of a particular application?
A common-condition study of 511 sequences from 29 organizations found different performance in improvement and ranking tasks. Cradle’s high-affinity candidate passed the aggregate threshold but retained concerns in individual developability assays.
- Blinded comparison under common conditionsRecorded
- Compare application-specific requirementsUnverified
- Reproducibility across targetsUnverified
New question opened
Distinguished antibody design, selection and development decisions, and recorded aggregate scoring alongside individual concerns.
NEXT CHECK
Reproducibility across targets, yield of candidates meeting required conditions, synthesis and assay counts, and cost and time to a development decision.
Evidence: PNAS / PubMed Central ↗Cradle ↗