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INSIGHT BANK · 31 LIVING CARDS

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Evidence, technologies, people and the next test—connected, but not confused.

Linked entity: MET · Clear

Commercializationv1 · 11.04

Why keep a drug after resistance emerges? ↗

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For which resistance profiles is it worth retaining EGFR inhibition and adding a MET inhibitor?

In phase 3 SAFFRON, 338 selected patients had median progression-free survival of 7.6 months with the combination and 5.4 months with chemotherapy.

  1. Phase 3 resultsRecorded
  2. Testing and uptakeUnverified
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Recorded phase 3 results for a combination matched to a resistance mechanism.

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Track the authorized population, testing criteria and the regimen’s place among later-line options.

Evidence: Clinical Lung Cancer ↗AstraZeneca ↗
Evidence, people & history ↗
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