Frontier Sciencev1 · 10.24
ACE levels are lower. Which functions have changed? ↗
Which changes in ACE abundance, catalytic activity or localization matter for neural function and disease?
The study reports lower ACE protein abundance associated with early-stage psychosis and treatment resistance, but no significant group difference in enzyme activity per unit serum volume.
- Association observed in patientsRecorded
- Disentangle functionsUnverified
- Causal links to diseaseUnverified
New question opened
Separate early-psychosis observations, prior depression research and editorial experimental proposals.
NEXT CHECK
Separate abundance, activity and localization in patient-derived cells and mice; distinguish circuit and behavioral measures from blood-pressure and locomotor effects.
Evidence: JAMA Psychiatry ↗Biological Psychiatry ↗